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Most solid tumors are plugged into the systemic circulation through the stroma , a mixture of non-malignant cells pertinent -but not limited- to the hosting tissue such as fibroblasts, nerve and immune cells, blood vessels, extracellular matrix proteins and adipocytes 20 , representing up to 90% of tumor mass 21

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The most potent compound of this series ( 17 ) was 53 times less potent than tadalafil (IC 50 = 160 nM) [238], with higher selectivity than tadalafil for PDE5 over PDE11) selectivity factor of 49 vs

SWL, CLY and CYW reviewed and revised the manuscript

Proc (bayl Univ Med Cent) 13(4):421423